Which of the following is a neuromuscular manifestation of serotonin syndrome?

Which of the following is a neuromuscular manifestation of serotonin syndrome?

• A. Hyperreflexia
• B. Diaphoresis
• C. Hyperthermia
• D. Nausea

Answer: (A)

Serotonin syndrome causes neuromuscular hyperactivity due to excessive serotonergic signaling in CNS and spinal pathways. Hyperreflexia is a classic neuromuscular sign, reflecting increased motor neuron excitability and exaggerated reflexes (often with tremor or myoclonus; clonus is also common). This is the best pick because it directly represents a neuromuscular manifestation. The other options are autonomic or gastrointestinal symptoms rather than neuromuscular signs: diaphoresis is sweating from autonomic instability, hyperthermia arises from autonomic dysregulation and increased metabolic activity, and nausea is a GI symptom.

Serotonin syndrome causes neuromuscular hyperactivity due to excessive serotonergic signaling in CNS and spinal pathways. Hyperreflexia is a classic neuromuscular sign, reflecting increased motor neuron excitability and exaggerated reflexes (often with tremor or myoclonus; clonus is also common). This is the best pick because it directly represents a neuromuscular manifestation.

The other options are autonomic or gastrointestinal symptoms rather than neuromuscular signs: diaphoresis is sweating from autonomic instability, hyperthermia arises from autonomic dysregulation and increased metabolic activity, and nausea is a GI symptom.