What is the onset of methadone after administration?

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Multiple Choice

What is the onset of methadone after administration?

Explanation:
Onset depends on the route of administration. When methadone is given intravenously, it acts rapidly—about 5 to 10 minutes to start producing effects. If it were given orally, absorption from the gut and first-pass metabolism slow things down, with onset typically around 30 to 60 minutes. The long duration is due to methadone’s extended half-life, but that doesn’t affect how quickly it begins to work when given IV. Therefore, the 5–10 minute window best reflects IV onset.

Onset depends on the route of administration. When methadone is given intravenously, it acts rapidly—about 5 to 10 minutes to start producing effects. If it were given orally, absorption from the gut and first-pass metabolism slow things down, with onset typically around 30 to 60 minutes. The long duration is due to methadone’s extended half-life, but that doesn’t affect how quickly it begins to work when given IV. Therefore, the 5–10 minute window best reflects IV onset.

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