Repeat dosing max every 4 minutes?

Repeat dosing max every 4 minutes?

• A. 5 mg/kg every 4 minutes
• B. 15 mg/kg every 2 minutes
• C. 20 mg/kg every 5 minutes
• D. 11.6 mg/kg every 4 minutes

Answer: (D)

Dosing within a fixed time window must not exceed the known maximum exposure in that window to avoid accumulation and toxicity. Here, convert each regimen to the amount delivered in a 4-minute period and compare to the safe per-4-minute maximum, which is 11.6 mg/kg. - 5 mg/kg given every 4 minutes delivers 5 mg/kg per 4-minute window, which stays below the limit but may be subtherapeutic depending on the needed effect. - 15 mg/kg every 2 minutes would deliver 30 mg/kg in 4 minutes, far above the safe 11.6 mg/kg per 4 minutes. - 20 mg/kg every 5 minutes would deliver 16 mg/kg per 4 minutes (since 20 mg/kg per 5 minutes equals 16 mg/kg per 4 minutes), exceeding the safe limit. - 11.6 mg/kg every 4 minutes delivers exactly the maximum safe exposure in that 4-minute window. Therefore, the regimen that provides the required effect without surpassing the per-4-minute safety ceiling is 11.6 mg/kg every 4 minutes.

Dosing within a fixed time window must not exceed the known maximum exposure in that window to avoid accumulation and toxicity. Here, convert each regimen to the amount delivered in a 4-minute period and compare to the safe per-4-minute maximum, which is 11.6 mg/kg.

• 5 mg/kg given every 4 minutes delivers 5 mg/kg per 4-minute window, which stays below the limit but may be subtherapeutic depending on the needed effect.

• 15 mg/kg every 2 minutes would deliver 30 mg/kg in 4 minutes, far above the safe 11.6 mg/kg per 4 minutes.

• 20 mg/kg every 5 minutes would deliver 16 mg/kg per 4 minutes (since 20 mg/kg per 5 minutes equals 16 mg/kg per 4 minutes), exceeding the safe limit.

• 11.6 mg/kg every 4 minutes delivers exactly the maximum safe exposure in that 4-minute window.

Therefore, the regimen that provides the required effect without surpassing the per-4-minute safety ceiling is 11.6 mg/kg every 4 minutes.