PRIS primarily affects which tissues due to energy failure?

PRIS primarily affects which tissues due to energy failure?

• A. Cardiac and skeletal muscles
• B. Brain and kidneys
• C. Skin and connective tissue
• D. Lymphoid organs

Answer: (A)

Propofol Infusion Syndrome causes mitochondrial dysfunction that impairs fatty acid oxidation and the electron transport chain, leading to reduced ATP production. Tissues with the highest demand for continuous, robust energy production are most vulnerable, especially the heart and skeletal muscle. When ATP generation falters, cardiac muscle function declines, producing cardiomyopathy and potential arrhythmias, while skeletal muscle undergoes rhabdomyolysis with risk of electrolyte disturbances and secondary kidney injury. These features explain why the primary tissues affected by energy failure in PRIS are the cardiac and skeletal muscles. Other tissues like skin/connective tissue, lymphoid organs, or the brain/kidneys are not the main targets of this energy-failure mechanism, though complications can occur secondarily.

Propofol Infusion Syndrome causes mitochondrial dysfunction that impairs fatty acid oxidation and the electron transport chain, leading to reduced ATP production. Tissues with the highest demand for continuous, robust energy production are most vulnerable, especially the heart and skeletal muscle. When ATP generation falters, cardiac muscle function declines, producing cardiomyopathy and potential arrhythmias, while skeletal muscle undergoes rhabdomyolysis with risk of electrolyte disturbances and secondary kidney injury. These features explain why the primary tissues affected by energy failure in PRIS are the cardiac and skeletal muscles. Other tissues like skin/connective tissue, lymphoid organs, or the brain/kidneys are not the main targets of this energy-failure mechanism, though complications can occur secondarily.