Fospropofol metabolism primarily occurs in which tissues?

Fospropofol metabolism primarily occurs in which tissues?

• A. Kidney and Liver
• B. Liver and Extrahepatic
• C. Brain
• D. Lungs

Answer: (B)

Fospropofol is a water-soluble prodrug that must be cleaved by tissue alkaline phosphatases to become active propofol. These enzymes are widespread, with high activity in the liver and in many extrahepatic tissues, so the dephosphorylation (and thus metabolism of the prodrug) occurs in both hepatic and nonhepatic sites. The brain and lungs aren’t the primary sites of this activation, while the liver handles the subsequent handling of the resulting propofol. Therefore, metabolism happens in the liver and other extrhepatic tissues.

Fospropofol is a water-soluble prodrug that must be cleaved by tissue alkaline phosphatases to become active propofol. These enzymes are widespread, with high activity in the liver and in many extrahepatic tissues, so the dephosphorylation (and thus metabolism of the prodrug) occurs in both hepatic and nonhepatic sites. The brain and lungs aren’t the primary sites of this activation, while the liver handles the subsequent handling of the resulting propofol. Therefore, metabolism happens in the liver and other extrhepatic tissues.